SB 203580 hydrochloride

• Catalog Number: orb1909166
• Category: Small Molecules
• Description: SB 203580 hydrochloride
• CAS Number: 869185-85-3
• MW: 413.9
• SMILES: Cl.CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
• Formula: C₂₁H₁₇ClFN₃OS
• Biological Activity: Adezmapimod (SB 203580) hydrochloride is a selective ATP-competitive inhibitor of p38 MAPK, displaying IC50 values of 50 nM for SAPK2a/p38 and 500 nM for SAPK2b/p38β2. This compound also inhibits LCK, GSK3β, and PKBα, albeit with IC50 values 100-500 times higher than those for SAPK2a/p38. Additionally, Adezmapimod hydrochloride acts as an activator of autophagy and mitophagy [1].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.