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SAR405
Catalog Number: orb1309129
| Catalog Number | orb1309129 |
|---|---|
| Category | Small Molecules |
| Description | SAR405 |
| CAS Number | 1523406-39-4 |
| Purity | 99.79% |
| MW | 443.85 |
| SMILES | C(N1C=2N(C(=O)C=C(N2)N3[C@H](C)COCC3)CC[C@H]1C(F)(F)F)C=4C=C(Cl)C=NC4 |
| Formula | C19H21ClF3N5O2 |
| Biological Activity | SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells. |
| Storage | Store at -20°C for 12 months. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
SAR405 R enantiomer [orb1218535]
> 98% (HPLC)
1946010-79-2
25 mg, 50 mg, 100 mg, 1 g, 500 mg, 200 mg, 2 mg, 5 mg, 10 mgSAR405 [orb611421]
[1523406-39-4]
443.8506
C19H21ClF3N5O2
10 mM * 1 mL in DMSO, 100 mg, 250 mg, 1000 mgSAR405 R enantiomer [orb1089905]
[1946010-79-2]
443.8505533
C19H21CLF3N5O2
10 mM * 1 mL in DMSO, 1 g, 250 mg, 100 mgSAR405 R enantiomer [orb1309130]
98.04%
1946010-79-2
443.85
C19H21ClF3N5O2
10 mg, 100 mg, 50 mg, 25 mg, 5 mg, 2 mg, 1 mg, 1 mL*10mM (in DMSO)
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