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SA09-Cu
Catalog Number: orb2278261
| Catalog Number | orb2278261 |
|---|---|
| Category | Small Molecules |
| Description | SA09-Cu is a potent, noncompetitive inhibitor of NDM-1, with an IC50 of 9.6 nM. It inactivates NDM-1 by oxidizing the enzyme's Zn(II)-thiolate site and resists reduction by bacterial intracellular thiols. SA09-Cu effectively restores Meropenem efficacy against various clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) and hampers the progression of carbapenem resistance [1]. |
| CAS Number | 155641-16-0 |
| Purity | 98.00% |
| MW | 364.03 |
| SMILES | N(CCO)(C)C=1[S-][Cu+2]2([S-]C(N(CCO)C)=[S]2)[S]1 |
| Formula | C8H16CuN2O2S4 |
| Biological Activity | SA09-Cu is a potent, noncompetitive inhibitor of NDM-1, with an IC50 of 9.6 nM. It inactivates NDM-1 by oxidizing the enzyme's Zn(II)-thiolate site and resists reduction by bacterial intracellular thiols. SA09-Cu effectively restores Meropenem efficacy against various clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) and hampers the progression of carbapenem resistance [1]. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
