S119-8

• Catalog Number: orb1309136
• Category: Small Molecules
• Description: S119-8
• CAS Number: 443639-96-1
• Purity: 99.83%
• MW: 344.45
• SMILES: N(C1=CC=C(NC(=O)C2=CC=C(C(C)(C)C)C=C2)C=C1)C3=CC=CC=C3
• Formula: C₂₃H₂₄N₂O
• Biological Activity: RN-18 antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation. RN-18 enhances Vif degradation only in the presence of A3G, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.