(S)-AM1241

• Catalog Number: orb1692270
• Category: Small Molecules
• Description: (S)-AM1241
• CAS Number: 444912-53-2
• Purity: 98%
• MW: 503.33
• SMILES: C(=O)(C=1C=2C(N(C[C@H]3N(C)CCCC3)C1)=CC=CC2)C4=CC(N(=O)=O)=CC=C4I
• Formula: C₂₂H₂₂IN₃O₃
• Biological Activity: (S)-AM1241 binds to cannabinoid (CB) receptors and is selective for the CB2 over the CB1 receptor (Kis = 658 and > 10,000 nM, respectively, in a membrane assay using human receptors). (S)-1241 acts as an agonist at human, rat, and mouse CB2 receptors but shows greater activity at human CB2 (EC50 = 131 nM) than at rat and mouse CB2 receptors (EC50 = 785 and 2,000 nM, respectively). Similar to the racemate AM1241 , (S)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing effect of (S)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone .
• Note: For research use only
• Expiration Date: 12 months from date of receipt.