(S)-3'-amino Blebbistatin

• Catalog Number: orb2283004
• Category: Small Molecules
• Description: (S)-3'-amino Blebbistatin
• CAS Number: 2097141-18-7
• MW: 307.35
• SMILES: O[C@]12C(N(CC1)C3=CC(N)=CC=C3)=NC=4C(C2=O)=CC(C)=CC4
• Formula: C₁₈H₁₇N₃O₂
• Biological Activity: "(S)-3'-amino Blebbistatin, retaining the active stereochemistry of the less stable and more phototoxic (–)-blebbistatin, serves as a refined selective cell-permeable inhibitor of non-muscle myosin II ATPases. This compound efficaciously inhibits the Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB across several species with IC50s ranging from 0.5-5 µM, and exhibits minimal inhibition against smooth muscle myosin (IC50= 80 µM). Its primary functions include obstructing apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. (S)-3'-amino Blebbistatin overcomes (–)-blebbistatin’s limitation of rapid degradation under blue light (450-490 nm) exposure, which generates cytotoxic intermediates, thus posing a challenge for fluorescent live cell imaging applications. The introduction of a 3’-amino group to its structure notably reduces fluorescence while maintaining (–)-blebbistatin’s activity, making it a superior alternative for research purposes."
• Note: For research use only
• Expiration Date: 12 months from date of receipt.