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Catalog Number | orb411596 |
---|---|
Category | Antibodies |
Description | Human monoclonal antibody to RSV |
Species/Host | Human |
Clonality | Monoclonal |
Clone Number | RSHZ19 (Felvizumab) |
Tested applications | ELISA |
Reactivity | Virus |
Isotype | IgG |
Immunogen | This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework. |
Concentration | 1 mg/ml |
Purity | Purified |
Conjugation | Unconjugated |
Target | RSV |
Storage | Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
Buffer/Preservatives | PBS with 0.02% Proclin 300. |
Alternative names | SB 209763; respiratory syncytial virus Read more... |
Note | For research use only |
Application notes | Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999). |
Expiration Date | 12 months from date of receipt. |
ELISA, FA, FACS, Kinetics | |
Virus | |
Monoclonal | |
Unconjugated |
ELISA, FA, FACS, Kinetics | |
Virus | |
Monoclonal | |
Unconjugated |
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