Rocaglamide (Rocaglamide A; Roc-A)

• Catalog Number: orb654635
• Category: Small Molecules
• Description: Rocaglamide (Rocaglamide A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia.
• CAS Number: [84573-16-0]
• MW: 505.55
• SMILES: OC1C2(O)C(C3C=CC(OC)=CC=3)(OC3C=C(OC)C=C(OC)C=32)C(C2C=CC=CC=2)C1C(N(C)C)=O
• Formula: C₂₉H₃₁NO₇
• Note: For research use only
• Expiration Date: 12 months from date of receipt.