RMC-6291

• Catalog Number: orb1818572
• Category: Small Molecules
• Description: RMC-6291 is a potent covalent inhibitor of KRASG12C(ON) that forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA). RMC-6291 overcomes limitations of first-generation KRASG12C(OFF) inhibitors in preclinical models by directly targeting the active form of this important oncogenic driver.
• CAS Number: [2641998-63-0]
• MW: 1012.261737
• SMILES: C(N1C2=CC=C3N4CCOC(CC(C(N5CCCC(N5)C(OCC(CC(C2=C3)=C1C1C=CC=NC=1C(C)OC)(C)C)=O)=O)NC(=O)C(C(C)C)N(C)C(C1(CCN(CC1)C(=O)C#CC(C)(C)N(C)C)F)=O)C4)C
• Formula: C₅₅H₇₈FN₉O₈
• Note: For research use only
• Expiration Date: 12 months from date of receipt.