Rineterkib

• Catalog Number: orb1089455
• Category: Small Molecules
• Description: Rineterkib, also known as LTT-462 or ERK-IN-1, is a RAF and ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models. LTT462 binds to and inhibits ERK, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in numerous tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.
• CAS Number: [1715025-32-3]
• MW: 578.42
• SMILES: N(C(C1C=CC(C2C(N)=NC=C([C@H]3CC[C@@H]([C@H](C3)F)O)N=2)=CC=1F)=O)[C@H](CNC)C1C=C(C=C(C=1)Br)F
• Formula: C₂₆H₂₇BRF₃N₅O₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.