You have no items in your shopping cart.
You have no items in your shopping cart.
Catalog Number | orb1568277 |
---|---|
Category | Small Molecules |
Description | RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.BT44 has no effect on TrkA and TrkB receptors; In GFRα1/RET expressing cells, 10–50?μM of BT44 increased the activity of luciferase reporter by approximately two fold (P<0.0001).BT44 dose-dependently stimulated neurite outgrowth from DRG sensory neurons and its efficacy was comparable to that of ARTN.BT44 alleviated mechanical hypersensitivity in surgery- and diabetes-induced rat models of neuropathic pain. |
CAS Number | [924759-42-2] |
MW | 577.595 |
SMILES | O=C(N1CCN(C2=CC(S(=O)(N3CC4=C(C=CC=C4)CC3)=O)=CC=C2OC)CC1)C5=CC=C(F)C=C5C(F)(F)F |
Formula | C28H27F4N3O4S |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
Filter by Rating