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Reelin Antibody / RELN
Catalog Number: orb2635417
| Catalog Number | orb2635417 |
|---|---|
| Category | Antibodies |
| Description | Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in reeler mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1, in a signaling pathway that controls cell positioning in the developing brain, and is also thought to be a direct effector of the neurotrophin BDNF. |
| Species/Host | Mouse |
| Clonality | Monoclonal |
| Clone Number | RELN/4498 |
| Tested applications | IHC-P |
| Reactivity | Human |
| Isotype | Mouse IgG2b |
| Immunogen | A portion of amino acids 1796-2115 was used as the immunogen for the Reelin antibody. |
| Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml |
| Conjugation | Unconjugated |
| Formula | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
| Hazard Information | This Reelin antibody is available for research use only. |
| UniProt ID | P78509 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Note | For research use only |
| Application notes | Optimal dilution of the Reelin antibody should be determined by the researcher. |
| Expiration Date | 12 months from date of receipt. |
IHC staining of FFPE human kidney tissue with Reelin antibody (clone RELN/4498). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Reelin antibody (clone RELN/4498) as confirmation of integrity and purity.
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