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RecombinantIL-21,Mouse
Catalog Number: orb1494824
| Catalog Number | orb1494824 |
|---|---|
| Category | Proteins |
| Description | Interleukin-21 (IL-21) belongs to the Type I four helix bundle cytokines, and shares the common cytokine receptor γ chain with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells. The IL-21 receptor is highly expressed on CD4+ and CD8+ B cells. IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells. IL-21regulates the production of IgG1 and IgE by B cells, and diminishes the severity of allergy and asthma. In some cases, IL-21 induces B cell apoptosis. Other roles of IL-21 include regulation of the innate immune system, implication in autoimmunity, and antitumor activity.Recombinant mouse interleukin-21 (IL-21) produced in E.coli is a single non-glycosylated polypeptide chain containing 123 amino acids. A fully biologically active molecule, rhIL-21 has a molecular mass of 15.1 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript. |
| Form/Appearance | Lyophilized after extensive dialysis against PBS. |
| Purity | > 95% as analyzed by SDS-PAGE. |
| MW | 15.1 kDa, observed by reducing SDS-PAGE. |
| Protein Sequence | MHKSSPQGP DRLLIRLRHL IDIVEQLKIY ENDLDPELLS APQDVKGHCE HAAFACFQKA KLKPSNPGNN KTFIIDLVAQ LRRRLPARRG GKKQKHIAKC PSCDSYEKRT PKEFLERLKW LLQKMIHQHL S |
| Source | Escherichia coli. |
| Biological Activity | ED50 1.0× 10ˆ6 units/mg. |
| Endotoxins | < 0.2 EU/μg, determined by LAL method. |
| Storage | Lyophilized recombinant mouse interleukin-21 (IL-21) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, mouse interleukin-21 (IL-21) should be stable up to 1 week at 4°C or up to 2 months at -20°C. |
| Buffer/Preservatives | Lyophilized after extensive dialysis against PBS. |
| Alternative names | Interleukin-21, IL21 Read more... |
| Note | For research use only |
| Application notes | Reconstituted in ddH2O or PBS at 100 μg/ml. |
| Expiration Date | 6 months from date of receipt. |
