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RecombinantIL-19,Mouse
Catalog Number: orb1494830
| Catalog Number | orb1494830 |
|---|---|
| Category | Proteins |
| Description | Interleukin-19 (IL-19) is a cytokine belonging to the interleukin family. Structurally, IL-19 is grouped into the IL-10 sub-family, which also includes IL-20, IL-22, IL-24, and IL-26. In contrast to IL-10, which exists as a homodimer, IL-19 is stable and active as a monomer in vivo. IL-19 functions through the receptor complex composed of IL-20 Receptor α and IL-20 Receptor β, which is also utilized by IL-20 and IL-24. IL-19 is produced by active monocytes and stimulated synergistically by IL-17 and IL-13. The functions of IL-19 are to promote the development and function of Th2 cells and to enhance the production of Th2 cytokines. IL-19 is implicated in aging, vascular disease, Type I diabetes, and rheumatoid arthritis. Recombinant mouse Interleukin-19 (rmIL-19) produced in E.coli is a single non-glycosylated polypeptide chain containing of153 amino acids. A fully biologically active molecule, rmIL-19 has a molecular mass of 17.7 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript. |
| Form/Appearance | Lyophilized after extensive dialysis against 50mM acetic acid. |
| Purity | > 95% by SDS-PAGE analysis. |
| MW | 17.7 kDa, observed by non-reducing SDS-PAGE. |
| Protein Sequence | MLRRCLISV DMRLIEKSFH EIKRAMQTKD TFKNVTILSL ENLRSIKPGD VCCMTNNLLT FYRDRVFQDH QERSLEVLRR ISSIANSFLC VQKSLERCQV HRQCNCSQEA TNATRIIHDN YNQLEVSSAA LKSLGELNIL LAWIDRNHLE TPAA |
| Source | Escherichia coli. |
| Biological Activity | ED50 2× 10ˆ4 units/mg. |
| Endotoxins | < 0.2 EU/μg, determined by LAL method. |
| Storage | Lyophilized recombinant mouse Interleukin-19 (rmIL-19) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmIL-19 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C. |
| Buffer/Preservatives | Lyophilized after extensive dialysis against 50mM acetic acid. |
| Alternative names | Interleukin-19, IL19 Read more... |
| Note | For research use only |
| Application notes | Reconstituted in 50 mM acetic acid at 50 μg/mL. |
| Expiration Date | 6 months from date of receipt. |
