Recombinant IL-19, Mouse

• Catalog Number: orb1494830
• Category: Proteins
• Description: Interleukin-19 (IL-19) is a cytokine belonging to the interleukin family. Structurally, IL-19 is grouped into the IL-10 sub-family, which also includes IL-20, IL-22, IL-24, and IL-26. In contrast to IL-10, which exists as a homodimer, IL-19 is stable and active as a monomer in vivo. IL-19 functions through the receptor complex composed of IL-20 Receptor α and IL-20 Receptor β, which is also utilized by IL-20 and IL-24. IL-19 is produced by active monocytes and stimulated synergistically by IL-17 and IL-13. The functions of IL-19 are to promote the development and function of Th2 cells and to enhance the production of Th2 cytokines. IL-19 is implicated in aging, vascular disease, Type I diabetes, and rheumatoid arthritis. Recombinant mouse Interleukin-19 (rmIL-19) produced in E.coli is a single non-glycosylated polypeptide chain containing of153 amino acids. A fully biologically active molecule, rmIL-19 has a molecular mass of 17.7 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
• Form/Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• MW: 17.7 kDa, observed by non-reducing SDS-PAGE.
• Protein Sequence: MLRRCLISV DMRLIEKSFH EIKRAMQTKD TFKNVTILSL ENLRSIKPGD VCCMTNNLLT FYRDRVFQDH QERSLEVLRR ISSIANSFLC VQKSLERCQV HRQCNCSQEA TNATRIIHDN YNQLEVSSAA LKSLGELNIL LAWIDRNHLE TPAA
• Source: Escherichia coli.
• Biological Activity: ED50 2× 10ˆ4 units/mg.
• Endotoxins: < 0.2 EU/μg, determined by LAL method.
• Storage: Lyophilized recombinant mouse Interleukin-19 (rmIL-19) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmIL-19 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
• Buffer/Preservatives: Lyophilized after extensive dialysis against 50mM acetic acid.
• Alternative names: Interleukin-19, IL19
• Note: For research use only
• Application notes: Reconstituted in 50 mM acetic acid at 50 μg/mL.
• Expiration Date: 6 months from date of receipt.