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Catalog Number | orb1494715 |
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Category | Proteins |
Description | Interleukin-17A (IL-17A),also known as CTLA-8 and IL-17, is a proinflammatory cytokine belonging to the IL-17 family. It is secreted by Th17 cells, gamma/delta T cells, NK cells and neutrophils. IL-17A signals through IL-17 receptor A in a complex with receptor C or D to regulate NF-kappaB and MAP kinase activities. IL-17A plays important roles in the anti-microbial response and chronic inflammation. It stimulates the production of IL-6, IL-8 and G-CSF in epithelial and endothelial cells, and induces the expression of ICAM-1 in fibroblasts. Clinically, IL-17A has been associated with inflammatory diseases, such as rheumatoid arthritis, psoriasis and multiple sclerosis.Recombinant human Interleukin-17A (rhIL-17A) produced in CHO cells is a glycosylated homodimer chain containing 142 amino acids. A fully biologically active molecule, rhIL-17A has a molecular mass of around 14-22 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript. |
Form/Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
MW | 14-22 kDa, observed by reducing SDS-PAGE. |
Protein Sequence | GITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINAD GNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVAHHHHHH |
Source | CHO |
Biological Activity | ED50 3.3×10ˆ6 units/mg. |
Endotoxins | < 0.2 EU/μg, determined by LAL method. |
Storage | Lyophilized recombinant humanInterleukin-17A (IL-17A), His remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human Interleukin-17A (IL-17A), His should be stable up to 1 week at 4°C or up to 2 months at -20°C. |
Buffer/Preservatives | Lyophilized after extensive dialysis against PBS. |
Alternative names | Interleukin-17A; IL-17A Read more... |
Note | For research use only |
Application notes | Reconstituted in ddH2O or PBS at 100 μg/ml. |
Expiration Date | 6 months from date of receipt. |
> 95% by Tris-Bis PAGE | |
KMP2028, Biotinylated Recombinant Human IL-17A&IL-17F heterodimer Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Gly24-Ala155(IL-17A)&Arg31-Gln163) of Human IL-17A&IL-17F heterodimer fused with His Tag and Avi tag at the C-terminal. |
> 95% by Tris-Bis PAGE, > 95% by SEC-HPLC | |
KMP2014, Recombinant Human IL-17A&IL-17F heterodimer Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Gly24-Ala155(IL-17A)&Arg31-Gln163) of Human IL-17A&IL-17F heterodimer fused with His Tag and Avi tag at the C-terminal. |
> 95% by SDS-PAGE. | |
KMP1521, Recombinant Human IL-17A Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Ile20-Ala155) of human IL-17A (Accession #NP_002181.1) fused with a 6×His Tag at the C-terminus. |
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