Recombinant Human Noggin

SKU: orb1921825

Description

Noggin is an extracellular cysteine knot protein that plays a crucial role in vertebrate dorsoventral patterning. Noggin binds and inhibits the activity of bone morphogenetic proteins (BMPs) via a conserved N-terminal clip domain. Noggin binds in vitro to most BMPs with no apparent dissociation, which suggests that the concentration of active ligand would be effectively decreased for all BMPs that it targets. Noggin was first described in the African Clawed Frog Xenopus laevis, where it is secreted from Spemann’s organizer and antagonizes BMP signaling. This activity generates a morphogen gradient along the dorsal-ventral axis, causing prospective ventral mesoderm to become dorsal mesoderm (dorsalization) and prospective epidermis to become neuroectoderm.

Images & Validation

• Application Notes:
  Application Notes: For research use only. Minimum Sample Size: 50μg/vial

Key Properties

• Source: CHO Cell
• Expression System: Eukaryotic cell
• Biological Origin: Human
• Molecular Weight: 22.87 kDa
• Purity: ≥95%
• Endotoxins: ≤10 EU/mg

Storage & Handling

• Storage: Use a manual defrost freezer and avoid repeated freeze - thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -102°C under sterile conditions after reconstitution.
• Form/Appearance: Lyophilized Powder
• Disclaimer: For research use only

Alternative Names

Symphalangism 1 (Proximal), Synostoses (Multiple) Syndrome 1, NOG, SYNS1

Quick Database Links

UniProt

Q13253

NCBI Gene ID

9241