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Recombinant Human Noggin
Catalog Number: orb1921825
| Catalog Number | orb1921825 |
|---|---|
| Category | Proteins |
| Description | Noggin is an extracellular cysteine knot protein that plays a crucial role in vertebrate dorsoventral patterning. Noggin binds and inhibits the activity of bone morphogenetic proteins (BMPs) via a conserved N-terminal clip domain. Noggin binds in vitro to most BMPs with no apparent dissociation, which suggests that the concentration of active ligand would be effectively decreased for all BMPs that it targets. Noggin was first described in the African Clawed Frog Xenopus laevis, where it is secreted from Spemann’s organizer and antagonizes BMP signaling. This activity generates a morphogen gradient along the dorsal-ventral axis, causing prospective ventral mesoderm to become dorsal mesoderm (dorsalization) and prospective epidermis to become neuroectoderm. |
| Form/Appearance | Lyophilized Powder |
| Purity | ≥95% |
| MW | 22.87 kDa |
| Entrez | 9241 |
| UniProt ID | Q13253 |
| Source | CHO Cell |
| Expression System | Eukaryotic cell |
| Biological Origin | Human |
| Endotoxins | ≤10 EU/mg |
| Storage | Use a manual defrost freezer and avoid repeated freeze - thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -102°C under sterile conditions after reconstitution. |
| Alternative names | Symphalangism 1 (Proximal), Synostoses (Multiple) Read more... |
| Note | For research use only |
| Application notes | Application Notes: For research use only. Minimum Sample Size: 50μg/vial |
| Expiration Date | 6 months from date of receipt. |
Recombinant Human Noggin, Insect Cells Derived [orb1906229]
> 95 % by SDS-PAGE and HPLC analyses.
Approximately 23.0 kDa on SDS-PAGE under reducing conditions, containing 205 amino acids, and a molecular mass about 47.9 kDa homodimer under non-reducing conditions (Molecular size on SDS-PAGE will appear at approximately 50-80 kDa).
Insect Cell
100 μg, 5 μg, 500 μgRecombinant Human Noggin [orb1906230]
> 95 % by SDS-PAGE and HPLC analyses.
Approximately 46.3 kDa, non-disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.
Escherichia coli
100 μg, 5 μg, 500 μgRecombinant Human Noggin (NOG) [orb1096190]
Greater than 85% as determined by SDS-PAGE.
58.2 kDa
E.coli
20 μg, 100 μg, 1 mgHuman Noggin (C-Fc) Protein [orb1471746]
Unconjugated
Greater than 95% as determined by reducing SDS-PAGE.
50.2 KDa
Mammalian
50 μg, 10 μgRecombinant Human Noggin Protein [orb1550440]
> 95% by Tris-Bis PAGE
KMP2049, Recombinant Human Noggin Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Gln28-Cys232) of Human Noggin fused with no tag .
500 μg, 100 μg
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