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Recombinant Human IL1a
Catalog Number: orb1921822
| Catalog Number | orb1921822 |
|---|---|
| Category | Proteins |
| Description | The interleukin (IL)-1 family member IL-1 is a ubiquitous and pivotal pro-inflammatory cytokine.IL-1 is constitutively expressed in epithelial, endothelial and stromal cells and can be upregulated in hematopoietic and non-hematopoietic cells by a number of stimuli, including TLR agonists, inflammatory cytokines, oxidative stress. IL-1 is translated into a 31-kDa precursor form (pro-IL-1).The pro-IL-1 could be cleaved by several protease to a 17-kDa mature form and a 16-kDa N terminal form. The mature form of IL-1 has higher biology activity compared to the pro-IL-1 as its binding affinity to its receptor is several folds higher than the pro-IL-1. IL-1 is a unique cytokine which could localize in the cytosol, membrane, nucleus, as well as being secreted out of the cell.IL-1 signaling pathway is triggered after binding of IL-1 to the IL-1RI. IL-1RI is found on the surface of various types of cells and, both IL-1 and IL-1 act on this same receptor. Binding of IL-1 to its receptor leads to dimerization of the receptor at the TIR domain and recruitment of IL-1R accessory protein, IL-1RAcP. This complex then recruits other adaptor protein, MyD88 and IRAK4. Formation of MyD88 and IRAK4 complex is a critical mediator in IL-1 signaling cascades. |
| Form/Appearance | Lyophilized Powder |
| Purity | ≥95% |
| MW | 18 kDa |
| Entrez | 3552 |
| UniProt ID | P01583 |
| Source | CHO Cell |
| Expression System | Eukaryotic cell |
| Biological Origin | Human |
| Endotoxins | ≤10 EU/mg |
| Storage | Use a manual defrost freezer and avoid repeated freeze - thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution. |
| Alternative names | IL1A,IL-1 ALPHA,IL1F1,IL1a Read more... |
| Note | For research use only |
| Application notes | Application Notes: For research use only. Minimum Sample Size: 50μg/vial |
| Expiration Date | 6 months from date of receipt. |
- Item 1 of 1
Human IL1 alpha protein (Active) [orb358965]
> 97% as determined by SDS-PAGE and HPLC.
18.0 kDa
E.Coli
500 μg, 10 μg, 100 μg - Item 1 of 1
- Item 1 of 1
- Item 1 of 1
Recombinant Human Interleukin-1 alpha (IL1A), Biotinylated [orb1096214]
Greater than 85% as determined by SDS-PAGE.
65.8 kDa
E.coli
20 μg, 100 μg, 1 mg - Item 1 of 1
Human IL1 alpha protein [orb604188]
Greater than 90% as determined by SDS-PAGE.
45 kDa
E.coli
20 μg, 100 μg, 1 mg
