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Recombinant Human IL1a
Catalog Number: orb1921822
| Catalog Number | orb1921822 |
|---|---|
| Category | Proteins |
| Description | The interleukin (IL)-1 family member IL-1 is a ubiquitous and pivotal pro-inflammatory cytokine.IL-1 is constitutively expressed in epithelial, endothelial and stromal cells and can be upregulated in hematopoietic and non-hematopoietic cells by a number of stimuli, including TLR agonists, inflammatory cytokines, oxidative stress. IL-1 is translated into a 31-kDa precursor form (pro-IL-1).The pro-IL-1 could be cleaved by several protease to a 17-kDa mature form and a 16-kDa N terminal form. The mature form of IL-1 has higher biology activity compared to the pro-IL-1 as its binding affinity to its receptor is several folds higher than the pro-IL-1. IL-1 is a unique cytokine which could localize in the cytosol, membrane, nucleus, as well as being secreted out of the cell.IL-1 signaling pathway is triggered after binding of IL-1 to the IL-1RI. IL-1RI is found on the surface of various types of cells and, both IL-1 and IL-1 act on this same receptor. Binding of IL-1 to its receptor leads to dimerization of the receptor at the TIR domain and recruitment of IL-1R accessory protein, IL-1RAcP. This complex then recruits other adaptor protein, MyD88 and IRAK4. Formation of MyD88 and IRAK4 complex is a critical mediator in IL-1 signaling cascades. |
| Form/Appearance | Lyophilized Powder |
| Purity | ≥95% |
| MW | 18 kDa |
| Entrez | 3552 |
| UniProt ID | P01583 |
| Source | CHO Cell |
| Expression System | Eukaryotic cell |
| Biological Origin | Human |
| Endotoxins | ≤10 EU/mg |
| Storage | Use a manual defrost freezer and avoid repeated freeze - thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution. |
| Alternative names | IL1A,IL-1 ALPHA,IL1F1,IL1a Read more... |
| Note | For research use only |
| Application notes | Application Notes: For research use only. Minimum Sample Size: 50μg/vial |
| Expiration Date | 6 months from date of receipt. |
- Item 1 of 2
Human IL1 alpha protein (Active) [orb358965]
> 97% as determined by SDS-PAGE and HPLC.
18.0 kDa
E.Coli
10 μg, 100 μg, 500 μg Human IL1A Protein, hFc Tag [orb1173724]
Unconjugated
The purity of the protein is greater than 90% as determined by SDS-PAGE and Coomassie blue staining.
The protein has a predicted molecular mass of 44.2 kDa after removal of the signal peptide.The apparent molecular mass of IL1A-hFc is approximately 35-55 kDa due to glycosylation.
Mammalian
100 μg, 10 μg, 50 μgHuman IL1 alpha protein [orb605342]
Greater than 90% as determined by SDS-PAGE.
20.0 kDa
Yeast
100 μg, 20 μg, 500 μg, 1 mgHuman IL1 alpha protein [orb605343]
Greater than 85% as determined by SDS-PAGE.
20.0 kDa
Yeast
100 μg, 20 μg, 500 μg, 1 mgHuman IL1 alpha protein [orb604188]
Greater than 90% as determined by SDS-PAGE.
45 kDa
E.coli
20 μg, 100 μg, 1 mg
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