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Catalog Number | orb1921849 |
---|---|
Category | Proteins |
Description | Interleukin-4 (IL-4) is a pleiotropic cytokine mainly produced by activated T lymphocytes, especially Th2 cells, mast cells, and basophils. Although the IL-4 cDNA sequence in human beings contains 153 amino acid residues, it can only produce secreted IL-4 proteins containing 129 amino acid residues. The spherical hydrophobic core of secreted IL-4 contains three disulfide bonds and four α-helices. After the addition of N-chain oligosaccharides, this core produces different molecular weights that include 15, 18, and 19 kDa. Essentially, secreted IL-4 mainly functions as follows: (1) driving Th2 cell differentiation to produce more IL-4, and then promoting the release of other Th2 anti-inflammatory CKs such as IL-5 and IL-13; (2) inhibiting the production of pro-inflammatory CKs such as TNF-α, interferon γ (IFN-γ), and IL-17; and (3) promoting B cell proliferation and differentiation and up-regulating the expression of major histocompatibility complex II (MHC II) molecules, IL-4R and CD23 on B cells. There are two types of IL-4 receptors, Type I and Type II. Type I receptors are a kind of heterodimer receptor that was formed by IL-4 receptor α (IL4Rα) and common r chain (γc) chains and are mainly expressed on the surface of hematopoietic cells. Type II receptors contain the IL4Rα and IL-13 receptor α1 (IL-13Rα1) and are expressed on the surface of non-hematopoietic cells. |
Form/Appearance | Lyophilized Powder |
Purity | ≥95% |
MW | 14.79 kDa |
Entrez | 3565 |
UniProt ID | P05112 |
Source | CHO Cell |
Expression System | Eukaryotic cell |
Biological Origin | Human |
Endotoxins | ≤10 EU/mg |
Storage | Use a manual defrost freezer and avoid repeated freeze - thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -73°C under sterile conditions after reconstitution. |
Alternative names | Interleukin 4, Lymphocyte Stimulatory Factor 1, B Read more... |
Note | For research use only |
Application notes | Application Notes: For research use only. Minimum Sample Size: 50μg/vial |
Expiration Date | 6 months from date of receipt. |
> 98% as determined by SDS-PAGE and HPLC. | |
15.0 kDa | |
E.Coli |
Greater than 95% as determined by SDS-PAGE. | |
15.1 kDa | |
E.coli |
Greater than 95% as determined by SDS-PAGE. | |
14.97 kDa | |
Mammalian cell |
Greater than 95% as determined by SDS-PAGE. | |
16 kDa | |
Mammalian cell |
ELISA, MS, SDS-PAGE, WB | |
Greater than 95% as determined by reducing SDS-PAGE. | |
Human cells |
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