Recombinant Human IL-21(hFc Tag)

• Catalog Number: orb1921843
• Category: Proteins
• Description: Interleukin (IL) -21 is a member of the common gamma chain (γc) family of cytokines and is expressed by multiple immune cell types, with activated CD4+ T cells, including T follicular helper (TFH) cells and natural killer (NK) T cells, being the major sources of this cytokine. The biological functions of IL-21 are mediated by binding to its corresponding receptor, IL-21R. IL-21R is expressed by a wide range of immune cells, including T and B cells, NK cells, DCs and macrophages as well as non-immune cells, including epithelial cells and keratinocytes. The IL-21/IL-21R signaling activates the JAK1/3-STAT, ,MAPK and PI3K signaling pathway. IL-21 has been proven to play an important role in the immune system, for example, by promoting proliferation and the development of TFH and Th17 cells, balancing helper T cell subsets, inducing B cell generation and differentiation into plasma cells, and enhancing the production of immunoglobulin. IL-21 levels are increased in the peripheral blood and tissues of patients with systematic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, immune thrombocytopenia, primary Sjogren’s syndrome, autoimmune thyroid disease and psoriasis.
• Form/Appearance: Lyophilized Powder
• Purity: ≥90%
• MW: 83.77 kDa
• Entrez: 59067
• UniProt ID: Q9HBE4
• Source: CHO Cell
• Expression System: Eukaryotic cell
• Biological Origin: Human
• Endotoxins: ≤10 EU/mg
• Storage: Use a manual defrost freezer and avoid repeated freeze - thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -79°C under sterile conditions after reconstitution.
• Alternative names: Interleukin 21, CVID11, Za11
• Note: For research use only
• Application notes: Application Notes: For research use only. Minimum Sample Size: 50μg/vial
• Expiration Date: 6 months from date of receipt.