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Recombinant Human CNTF Protein

Recombinant Human CNTF Protein

Catalog Number: orb527077

DispatchUsually dispatched within 3-4 weeks
$ 370.00
Catalog Numberorb527077
CategoryProteins
DescriptionCiliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor β subunit, and a CNTF specific α receptor subunit. Upon binding to the CNTF, the β subunit of the CNTF receptorwill undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons. Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE.
ReactivityHuman
Form/AppearanceLyophilized
MW21.7KD
UniProt IDP26441
Protein SequenceHRRDL CSRSI WLARK IRSDL TALTE SYVKH QGLNK NINLD SADGM PVAST DQWSE LTEAE RLQEN LQAYR TFHVL LARLL EDQQV HFTPT EGDFH QAIHT LLLQV AAFAY QIEEL MILLE YKIPR NEADG MPINV GDGGL FEKKL WGLKV LQELS QWTVR SIHDL RFISS HQTGI PARGS HYIAN NKKM
SourceE. coli His12-Met200
EndotoxinsLess than 1 EU/μg of rhCNTF as determined by LAL method.
StorageLyophilized recombinant human Ciliary Neurotrophic Factor (rhCNTF)remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhCNTF remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
NoteFor research use only
Expiration Date6 months from date of receipt.
  • Human CNTF protein (Active) [orb359177]

    > 97% as determined by SDS-PAGE and HPLC.

    22.9 kDa

    E.Coli

    5 μg, 100 μg, 500 μg
  • CNTF (Human) Recombinant Protein (P01) [orb2289700]

    AP,  Array,  ELISA,  WB

    10 μg
  • Human CNTF Protein [orb1471705]

    Greater than 95% as determined by reducing SDS-PAGE.

    22.93 KDa

    Mammalian

    50 μg, 10 μg
  • Human CNTF protein [orb603982]

    Greater than 90% as determined by SDS-PAGE.

    26.1 kDa

    E.coli

    20 μg, 100 μg, 1 mg
  • Human CNTF protein [orb594966]

    Greater than 85% as determined by SDS-PAGE.

    26.8 kDa

    Baculovirus

    20 μg, 100 μg, 1 mg