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Recombinant GZMB Antibody / Granzyme B

Catalog Number: orb2635530

DispatchUsually dispatched within 5-10 working days
$ 780.00
Catalog Numberorb2635530
CategoryAntibodies
DescriptionGranzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.
Species/HostMouse
ClonalityRecombinant
Clone NumberrGZMB/4538
Tested applicationsIHC-P, WB
ReactivityHuman
IsotypeMouse IgG2a, kappa
ImmunogenA portion of amino acids 73-187 was used as the immunogen for the recombinant GZMB antibody.
Antibody TypePrimary Antibody
Dilution rangeWestern blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml
ConjugationUnconjugated
Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Hazard InformationThis recombinant GZMB antibody is available for research use only.
UniProt IDP10144
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
NoteFor research use only
Application notesOptimal dilution of the recombinant GZMB antibody should be determined by the researcher.
Expiration Date12 months from date of receipt.
Recombinant GZMB Antibody / Granzyme B

Western blot testing of human spleen tissue lysate using recombinant GZMB antibody (clone rGZMB/4538). Predicted molecular weight: 29-37 kDa.

Recombinant GZMB Antibody / Granzyme B

IHC staining of FFPE human tonsil tissue with recombinant GZMB antibody (clone rGZMB/4538). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

Recombinant GZMB Antibody / Granzyme B

IHC staining of FFPE human spleen tissue with recombinant GZMB antibody (clone rGZMB/4538). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

Recombinant GZMB Antibody / Granzyme B

SDS-PAGE analysis of purified, BSA-free recombinant GZMB antibody (clone rGZMB/4538) as confirmation of integrity and purity.

  • Recombinant GZMB Antibody / Granzyme B [orb2635528]

    IHC-P,  WB

    Human

    Mouse

    Recombinant

    Unconjugated

    100 μg
  • Recombinant GZMB Antibody / Granzyme B [orb2635529]

    IHC-P,  WB

    Human

    Mouse

    Recombinant

    Unconjugated

    20 μg