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Catalog Number | orb1494863 |
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Category | Proteins |
Description | Fibroblast Growth Factor-basic (FGF-basic), also known as FGF-2, is a pleiotropic cytokine and one of the prototypic members of the heparin-binding FGF family. Like other FGF family members, FGF-basic has the β trefoil structure. In vivo, FGF-basic is produced by a variety of cells, including cardiomycotes, fibroblasts, and vascular cells. FGF-basic regulates a variety of processes including cell proliferation, differentiation, survival, adhesion, motility, apoptosis, limb formation and wound healing. FGF-basic can be tumorigenic due to its role in angiogenesis and blood vessel remodeling. The angiogenic effects of FGF-basic can produce beneficial cardioprotection during acute heart injury.Recombinant rat Fibroblast Growth Factor-basic (rrFGF-basic) produced in E.coli is a single non-glycosylated polypeptide chain containing 146 amino acids. A fully biologically active molecule, rrFGF-basic has a molecular mass of 16.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript. |
Form/Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
MW | 16.4 kDa, observed by reducing SDS-PAGE. |
Protein Sequence | GP ALPEDGGGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHVK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTEEC FFFERLESNN YNTYRSRKYS SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS |
Source | Escherichia coli. |
Biological Activity | ED50 4 × 10ˆ6 units/mg. |
Endotoxins | < 0.2 EU/μg, determined by LAL method. |
Storage | Lyophilized recombinant rat Fibroblast Growth Factor-basic (rrFGF-basic) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rrFGF-basic remains stable up to 2 weeks at 4°C or up to 3 months at -20°C. |
Buffer/Preservatives | Lyophilized after extensive dialysis against PBS. |
Alternative names | Fibroblast Growth Factor-basic, FGF-2, FGF2, HBGF- Read more... |
Note | For research use only |
Application notes | Reconstituted in ddH2O at 100 μg/mL. |
Expiration Date | 6 months from date of receipt. |
> 95% by SDS-PAGE. | |
KMP1783, Recombinant Rat FGF-2/FGF basic/bFGF Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala11-Ser154) of rat FGF-2/FGF basic/bFGF (Accession #P13109). |
≥90% as determined by SDS-PAGE | |
This protein contains the rat FGF2(Ala11-Ser154) was fused without Tag and expressed in E. coli. |
> 98 % by SDS-PAGE and HPLC analyses. | |
Approximately 16.4 kDa, a single non-glycosylated polypeptide chain containing 146 amino acids. | |
Rat |
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