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Recombinant FGF-12, Human
Catalog Number: orb1494885
| Catalog Number | orb1494885 |
|---|---|
| Category | Proteins |
| Description | Fibroblast Growth Factor-12(FGF-12) is a heparin binding cytokine belonging to the FGF family. FGF-12 along with FGF-11, -13, and -14, form a sublineage within the FGF family: in contrast to the other members, they are all intracellular signaling proteins lacking signal peptides and containing a flanking domain beside the family conserved β-trefoil domain. FGF-12 is expressed in the cartilaginous skeleton and heart, suggesting a role in the development of connective tissue and heart. In vivo, FGF-12 binds to Islet Brain-2 and Voltage-Gated Sodium Channels (VGSC), and plays a critical role in the membrane targeting and function of VGSC. FGF-12 has been implicated in heart diseases such as cardiac arrhythmias.Recombinant human Fibroblast Growth Factor-12 (rhFGF-12) produced in E.coli is a single non-glycosylated polypeptide chain containing 181 amino acids. A fully biologically active molecule, rhFGF-12 has a molecular mass of 20.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript. |
| Form/Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| MW | 20.4 kDa, observed by reducing SDS-PAGE. |
| Protein Sequence | MESKEPQLK GIVTRLFSQQ GYFLQMHPDG TIDGTKDENS DYTLFNLIPV GLRVVAIQGV KASLYVAMNG EGYLYSSDVF TPECKFKESV FENYYVIYSS TLYRQQESGR AWFLGLNKEG QIMKGNRVKK TKPSSHFVPK PIEVCMYREP SLHEIGEKQG RSRKSSGTPT MNGGKVVNQD ST |
| Source | Escherichia coli. |
| Biological Activity | ED50 5×10ˆ4 units/mg. |
| Endotoxins | < 0.2 EU/μg, determined by LAL method. |
| Storage | Lyophilized recombinant human Fibroblast Growth Factor-12 (rhFGF-12) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhFGF-12 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C. |
| Buffer/Preservatives | Lyophilized after extensive dialysis against PBS. |
| Alternative names | FHF1, FGF12B Read more... |
| Note | For research use only |
| Application notes | Reconstituted in ddH2O or PBS at 100 μg/ml. |
| Expiration Date | 6 months from date of receipt. |
Human FGF12 protein [orb391723]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by reducing SDS-PAGE.
E. coli
500 μg, 50 μg, 10 μgHuman FGF-12 Protein [orb1471742]
Unconjugated
Greater than 95% as determined by reducing SDS-PAGE.
20.45 KDa
E. Coli
10 μg, 50 μgRecombinant FGF-12 (Fibroblast growth factor-12), Human, AF [orb1179126]
ELISA
> 98% as determined by SDS-PAGE. Ni-NTA chromatography.
Escherichia coli
100 μg, 1 mg, 500 μg, 20 μg, 5 μgRecombinant Human FGF-12 Protein, His Tag [orb1551397]
> 97% by SDS-PAGE.
KMP1090, Recombinant Human FGF-12 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Thr181) of human FGF-12 (Accession #NP_004104.3) fused with a 6×His Tag at the C-terminus.
50 μg, 20 μgRecombinant Human FGF-12 Protein, No Tag [orb1552408]
≥90% as determined by SDS-PAGE
This protein contains the human FGF12(Met1-Thr181) was fused without Tag and expressed in E. coli.
100 μg, 50 μg
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