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    Recombinant AITRL, Mouse

    Recombinant AITRL, Mouse

    Catalog Number: orb1494907

    DispatchUsually dispatched within 5-10 working days
    $ 544.00
    Catalog Numberorb1494907
    CategoryProteins
    DescriptionActivation-Inducible TNF-Related Ligand (AITRL), also known as Glucocorticoid-Induced TNF-Related Ligand (GITRL), belongs to the tumor necrosis factor superfamily (TNFSF). AITRL is a Type II single transmembrane protein and shares low conservation within the extracellular domain with other TNFSF members. AITRL is expressed on macrophages, immature and mature dendritic cells and B cells. Its receptor, Activation-Inducible TNFR family Receptor (AITR), is expressed on T lymphocytes, natural killer (NK) cells, and antigen- presenting cells. After binding by AITRL, AITR can be released. AITR activation increases resistance to tumors and viral infections and is involved in autoimmune and inflammatory processes. In addition, activated AITR increases TCR-induced T cell proliferation and cytokine production and rescues T cells and NK cells from apoptosis. Recombinant mouse Activation-Inducible TNF-Related Ligand (rmAITRL) produced in E.coli is a single non-glycosylated polypeptide chain containing 127 amino acids. A fully biologically active molecule, rmAITRL has a molecular mass of 14.5 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
    Form/AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
    MW14.5 kDa, observed by reducing SDS-PAGE.
    Protein SequenceTAI ESCMVKFELS SSKWHMTSPK PHCVNTTSDG KLKILQSGTY LIYGQVIPVD KKYIKDNAPF VVQIYKKNDV LQTLMNDFQI LPIGGVYELH AGDNIYLKFN SKDHIQKTNT YWGIILMPDL PFIS
    SourceEscherichia coli.
    Biological ActivityED50 2.0 × 10ˆ5 units/mg.
    Endotoxins< 0.2 EU/μg, determined by LAL method.
    StorageLyophilized recombinant mouse Activation-Inducible TNF-Related Ligand (rmAITRL) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmAITRL remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
    Buffer/PreservativesLyophilized after extensive dialysis against PBS.
    Alternative namesActivation-induced TNFR member Ligand, TNFSF18, GI
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    NoteFor research use only
    Application notesReconstituted in ddH2O at 100 μg/mL.
    Expiration Date6 months from date of receipt.
    • Human GITR Ligand Protein, mFc-His tag [orb689381]

      Unconjugated

      The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

      The protein has a predicted molecular mass of 46-53 kDa after removal of the signal peptide.

      Mammalian

      10 μg, 50 μg, 100 μg
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