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Recombinant AITRL, Human
Catalog Number: orb1494908
| Catalog Number | orb1494908 |
|---|---|
| Category | Proteins |
| Description | Activation-Inducible TNF-Related Ligand (AITRL), also known as Glucocorticoid-Induced TNF-Related Ligand (GITRL), belongs to the tumor necrosis factor superfamily (TNFSF). AITRL is a Type II single transmembrane protein and shares low conservation within the extracellular domain with other TNFSF members. AITRL is expressed on macrophages, immature and mature dendritic cells and B cells. Its receptor, Activation-Inducible TNFR family Receptor (AITR), is expressed on T lymphocytes, natural killer (NK) cells, and antigen-presenting cells. Upon binding by AITRL, AITR can be released. AITR activation increases resistance to tumors and viral infections and is involved in autoimmune and inflammatory processes. In addition, activated AITR increases TCR-induced T cell proliferation and cytokine production and rescues T cells and NK cells from apoptosis. Recombinant human Activation-Inducible TNF-Related Ligand (rhAITRL) produced in E.coli is a single non-glycosylated polypeptide chain containing 126 amino acids. A fully biologically active molecule, rhAITRL has a molecular mass of 14.3 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript. |
| Form/Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| MW | 14.3 kDa, observed by reducing SDS-PAGE. |
| Protein Sequence | METAKEPCM AKFGPLPSKW QMASSEPPCV NKVSDWKLEI LQNGLYLIYG QVAPNANYND VAPFEVRLYK NKDMIQTLTN KSKIQNVGGT YELHVGDTID LIFNSEHQVL KNNTYWGIIL LANPQFI |
| Source | Escherichia coli. |
| Biological Activity | ED50 2.0 × 10ˆ5 units/mg. |
| Endotoxins | < 0.2 EU/μg, determined by LAL method. |
| Storage | Lyophilized recombinant human Activation-Inducible TNF-Related Ligand (rhAITRL) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhAITRL remains stable up to 2 weeks at 4°C or up to 3 months at -20°C. |
| Buffer/Preservatives | Lyophilized after extensive dialysis against 50 mM Tris, pH 8.0. |
| Alternative names | Activation-induced TNFR member Ligand, TNFSF18, GI Read more... |
| Note | For research use only |
| Application notes | Reconstituted in ddH2O at 100 μg/mL. |
| Expiration Date | 6 months from date of receipt. |
Human GITR Ligand Protein, mFc-His tag [orb689381]
Unconjugated
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
The protein has a predicted molecular mass of 46-53 kDa after removal of the signal peptide.
Mammalian
10 μg, 50 μg, 100 μgHuman GITR Ligand Protein, His tag [orb689462]
Unconjugated
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
The protein has a predicted molecular mass of 15.3 kDa after removal of the signal peptide.
Mammalian
10 μg, 50 μg, 100 μgHuman TNFSF18 protein [orb392618]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by reducing SDS-PAGE.
Human cells
500 μg, 50 μg, 10 μgRecombinant AITRL (Activation-induced TNFR member ligand), Human, AF [orb1179175]
ELISA
> 98% as determined by SDS-PAGE. Ni-NTA chromatography.
Escherichia coli
20 μg, 1 mg, 500 μg, 100 μg, 5 μgRecombinant Human TNFSF18 Protein, Fc & His Tag [orb1550645]
> 95% by SDS-PAGE.
KMP1844, Recombinant Human TNFSF18 Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (mFc(Pro99-Lys330)&GITR Ligand(Gln50-Ser177)) of human TNFSF18 (Accession #) fused with a Fc and His Tag at the N-terminal.
50 μg, 100 μg
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