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Catalog Number | orb1146652 |
---|---|
Category | Small Molecules |
Description | Rasarfin is a novel dual Ras and ARF6 inhibitor. Rasarfin blocks agonist-mediated internalization of AT1R and other GPCRs. Rasarfin also potently inhibits agonist-induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR, as well as prevents cancer cell proliferation. In silico modeling and in vitro studies reveal a unique binding modality of Rasarfin within the SOS-binding domain of Ras. Rasarfin is a novel dual Ras and ARF6 inhibitor. Rasarfin blocks agonist-mediated internalization of AT1R and other GPCRs. Rasarfin also potently inhibits agonist-induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR, as well as prevents cancer cell proliferation. In silico modeling and in vitro studies reveal a unique binding modality of Rasarfin within the SOS-binding domain of Ras. |
CAS Number | [674359-73-0] |
MW | 425.1506 |
SMILES | O=C(C1=CC2=CC=CC=C2O1)NC3=CC=C(N4CCN(C(C(C)C)=O)CC4)C(Cl)=C3 |
Formula | C23H24ClN3O3 |
Hazard Information | Non-Toxic |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
98.58% | |
674359-73-0 | |
425.91 | |
C23H24ClN3O3 |
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