Randox - Pregnancy Associated Plasma Protein-1 (PAPP-1A)

• Catalog Number: RCP9145
• Category: Proteins
• Description: PAPP-A is a large zinc binding protein, which acts as a metalloprotease and has been shown to cleave insulin-like growth factor binding protein-4. PAPP-A can act as a regulator of IGF bioactivity in several biological systems, including the human ovary and cardiovascular systems. Recent studies have shown that levels are elevated in patients with unstable angina or acute myocardial infarction. PAPP-A is also produced in high concentrations during pregnancy and is released into the maternal circulation. Low levels of PAPP-A have been linked with a number of foetal chromosomal abnormalities, as well as pre-eclampsia and stillbirth.
• Tag: N terminal containing a HIS tag
• Form/Appearance: Liquid
• Purity: > 95 %, by SDS-PAGE under reducing conditions
• MW: 25.75 kDa
• UniProt ID: Q13219
• Protein Length: Arg81-Asp271
• Source: E.coli -derived human recombinant protein
• Expression System: E.coli
• Storage: at -20 °C
• Buffer/Preservatives: 20mM Tris HCl pH 8, 50% Glycerol, 4M Urea
• Alternative names: Pappalysin-1; Pregnancy-Associated Plasma Protein-
• Note: For research use only
• Application notes: ELISA, Western Blotting, etc.
• Expiration Date: 6 months from date of receipt.