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Catalog Number | orb1307324 |
---|---|
Category | Small Molecules |
Description | Belinostat |
CAS Number | 414864-00-9 |
Purity | 99.93% |
MW | 318.35 |
SMILES | ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1 |
Formula | C15H14N2O4S |
Biological Activity | Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase. |
Storage | -20°C |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |