R-DOTAP(DOTAP R-isomer )

• Catalog Number: orb1785916
• Category: Small Molecules
• Description: 1,2-Dioleoyl-3(R)-trimethylammoniumpropane (R-DOTAP) is a cationic lipid and the more immunologically active isomer of DOTAP.Lipoplexes containing R-DOTAP and encapsulating siRNA targeting the gene encoding aromatase, CYP19A1, decrease aromatase activity in MCF-7 breast cancer cells.1 Vaccination with a peptide epitope from human papillomavirus (HPV) 16 protein E7 in R-DOTAP-containing liposomes induces IFN-γ production by CD8+ T cells and tumor-infiltrating lymphocytes (TILs) and decreases tumor size in a murine cervical cancer model.2 Subcutaneous immunization with recombinant influenza B hemagglutinin using R-DOTAP as an adjuvant increases IL-2 and IFN-γ production in CD4+ T cells isolated from mouse draining lymph nodes and spleen.
• CAS Number: [328250-28-8]
• MW: 698.5
• SMILES: CCCCCCCC/C=C\CCCCCCCC(O[C@H](C[N+](C)(C)C)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O
• Formula: C₄₂H₈₀NO₄.Cl
• Note: For research use only
• Expiration Date: 12 months from date of receipt.