(R)-AM1241

• Catalog Number: orb1692371
• Category: Small Molecules
• Description: (R)-AM1241
• CAS Number: 444912-51-0
• Purity: 98%
• MW: 503.33
• SMILES: C(=O)(C=1C=2C(N(C[C@@H]3N(C)CCCC3)C1)=CC=CC2)C4=CC(N(=O)=O)=CC=C4I
• Formula: C₂₂H₂₂IN₃O₃
• Biological Activity: (R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts as an agonist at human CB2 receptors (EC50 = 118 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 315 and 341 nM, respectively). Similar to the racemate AM1241 , (R)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing effect of (R)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone .
• Note: For research use only
• Expiration Date: 12 months from date of receipt.