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Catalog Number | orb1304561 |
---|---|
Category | Small Molecules |
Description | Pyridone 6 |
CAS Number | 457081-03-7 |
Purity | 98.70% |
MW | 309.34 |
SMILES | C(C)(C)(C)C=1NC=2C(=C3C(=C4C2C=CC(F)=C4)C(=O)NC=C3)N1 |
Formula | C18H16FN3O |
Biological Activity | Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases. |
Storage | Store at -20°C for 12 months. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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