Pyr10

• Catalog Number: orb1307830
• Category: Small Molecules
• Description: Pyr10
• CAS Number: 1315323-00-2
• Purity: 99.70%
• MW: 449.37
• SMILES: C(F)(F)(F)C=1N(N=C(C(F)(F)F)C1)C2=CC=C(NS(=O)(=O)C3=CC=C(C)C=C3)C=C2
• Formula: C₁₈H₁₃F₆N₃O₂S
• Biological Activity: Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) (IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells) .
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.