Py-MAA-Val-Cit-PAB-MMAE

• Catalog Number: orb2279062
• Category: Small Molecules
• Description: Py-MAA-Val-Cit-PAB-MMAE
• CAS Number: 2247398-68-9
• MW: 1446.79
• SMILES: [C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC3=CC=C(NC([C@@H](NC([C@@H](NC(CSCCC(=O)N4CN(C(C=C)=O)CN(C(C=C)=O)C4)=O)[C@H](C)C)=O)CCCNC(N)=O)=O)C=C3)=O)C)C(C)C)=O)[C@@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
• Formula: C₇₂H₁₁₁N₁₃O₁₆S
• Biological Activity: Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) serves as an ADC linker for Zapadcine-3a, a broad-spectrum anti-TRAILR2 ADC with antineoplastic properties. By targeting TRAILR2, Zapadcine-3a is internalized into the lysosomes of tumor cells, where it subsequently releases a small molecular compound that selectively eradicates TRAILR2-positive tumor cells, potentially leading to tumor remission [1].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.