PXS-5153A monohydrochloride

• Catalog Number: orb1708782
• Category: Small Molecules
• Description: PXS-5153A monohydrochloride
• CAS Number: 2125956-82-1
• Purity: 98%
• MW: 475.41
• SMILES: CC1=C(C2=CC(S(=O)(N(C)C)=O)=CC=C2)C3=C(C=CC=N3)N1C/C(F)=C/CN.Cl.Cl
• Formula: C₂₀H₂₄ClFN₄O₂S
• Biological Activity: PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC 50 of < 40 nM for LOXL2 across all mammalian species and an IC 50 of 63 nM for human LOXL3. PXS-5153A monohydrochloride dose-dependently reduced LOXL2-mediated collagen oxidation and collagen crosslinking in vitro which may represent an innovative therapeutic approach for the treatment of fibrosis
• Note: For research use only
• Expiration Date: 12 months from date of receipt.