PT2977

• Catalog Number: orb654569
• Category: Small Molecules
• Description: PT2977 (MK-6482) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. PT2977, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC)[1].
• CAS Number: [1672668-24-4]
• MW: 383.34
• SMILES: N#CC1C=C(OC2C3[C@H]([C@H]([C@@H](O)C=3C(S(=O)(C)=O)=CC=2)F)F)C=C(F)C=1
• Formula: C₁₇H₁₂F₃NO₄S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.