Prucalopride Succinate

SKU: orb1300311

Description

Prucalopride Succinate

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 179474-85-2
• MW: 485.96
• Purity: 99.24%
• Formula: C₁₈H₂₆ClN₃O₃·C₄H₆O₄
• SMILES: OC(=O)CCC(O)=O.COCCCN1CCC(CC1)NC(=O)C1=C2OCCC2=C(N)C(Cl)=C1
• Target: Autophagy,Apoptosis,5-HT Receptor
• Solubility: H2O:89 mg/mL (183.14 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.79 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:90 mg/mL (185.2 mM)

Bioactivity

• Target IC50:
  5 hT4B:8 nM(Ki)|5 hT4A:2.5 nM(Ki)
• In Vivo:
  Prucalopride alters colonic contractile motility patterns in a dose-dependent fashion by stimulating high-amplitude clustered contractions in the proximal colon and by inhibiting contractile activity in the distal colon of fasted dogs. Prucalopride also causes a dose-dependent decrease in the time to the first giant migrating contraction (GMC); at higher doses of prucalopride the first GMC generally occurres withi the first half-hour after treatment.
• In Vitro:
  Prucalopride induces contractions in a concentration dependent manner with pEC50 of 7.5. Prucalopride (1 mM significantly amplifie the rebound contraction o the guinea-pig proximal colon after electrical ffield stimulation. Prucalopride induces relaxation o the rat oesophagus preparation of rat oesophagus tunica muscularis mucosae with pEC50 of 7.8, yielding a monophasic concentration response curve. Prucalopride (0.1 μM) concentration dependently increase the amplitude of submaximal cholinergic contractions and of acetylcholine release induced by electrical ffield stimulation in pig gastric circular musclee, an the effect is induced and enhanced IBMX (10 μM). Prucalopride (1 μM) significantly enhance the electrically induced cholinergic contractions in pig descending colon, an the facilitating effect is significantly enhanced by Rolipram.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, 5-HT Receptor, 5-hydroxytryptamine Receptor, 5HTReceptor, 5-HT4A, 5-HT4B, 5HT Receptor, Resolor Succinate, Serotonin Receptor, R108512, R-108512, R 108512, Prucalopride, Prucalopride Succinate

Compound Identifiers

PubChem CID

9870009