Propylthiouracil

• Catalog Number: orb1309031
• Category: Small Molecules
• Description: Propylthiouracil
• CAS Number: 51-52-5
• Purity: 99.94%
• MW: 170.23
• SMILES: CCCC1=CC(O)=NC(S)=N1
• Formula: C₇H₁₀N₂OS
• Biological Activity: Propylthiouracil is a thiourea derivative with an antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triiodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.