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pro-BDNF Protein, Human, Recombinant
Catalog Number: orb1962090
| Catalog Number | orb1962090 |
|---|---|
| Category | Proteins |
| Description | The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain. |
| Tag | Tag Free |
| Purity | 99.00% |
| MW | 28 KDa (reducing condition) |
| UniProt ID | P23560 |
| Protein Sequence | Ala19-Arg247(R125A,R127A,R128A) |
| Expression System | E. coli |
| Biological Origin | Human |
| Biological Activity | The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain. |
| Expression Region | Ala19-Arg247(R125A,R127A,R128A) |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 6 months from date of receipt. |
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Human pro-BDNF Protein [orb1471731]
Greater than 95% as determined by reducing SDS-PAGE.
25.6 KDa
Mammalian
10 μg, 50 μg Human BDNF protein [orb391293]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
E. coli
500 μg, 50 μg, 10 μg
