PR 619

• Catalog Number: orb1140611
• Category: Small Molecules
• Description: Broad spectrum deubiquitinylating enzyme (DUB) inhibitor; Small molecules.
• CAS Number: 2645-32-1
• Structure: 2,6-Diamino-3,5-dithiocyanopyridine
• Target Areas: Deubiquitinating enzymes
• Form/Appearance: Light brown solid
• Purity: > 98% by hplc
• MW: 223.28 Da
• Formula: C₇H₅N₅S₂
• Solubility (25°C): Soluble to 10 mM in DMSO
• Protein Sequence: 2,6-Diamino-3,5-dithiocyanopyridine
• Storage: Store desiccated, frozen and in the dark
• Alternative names: 2645-32-1, DUBsPI150, PR 619, PR619, cancer, deubi
• Background: PR 619 is a broad spectrum, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with an EC50 of 1-20 µM in a cell-free assay and only limited activity against other proteases. PR 619 induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. PR 619 is cytotoxic in HEK293T and colorectal cancer cells and stabilizes microtubule networks in oligodendroglial cells.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.