Pimasertib HCl

• Catalog Number: orb1738317
• Category: Small Molecules
• Description: Pimasertib HCl
• CAS Number: 1236361-78-6
• Purity: 0.98
• MW: 467.66
• SMILES: Cl.OC[C@@H](O)CNC(=O)c1ccncc1Nc1ccc(I)cc1F
• Formula: C₁₅H₁₆ClFIN₃O₃
• Biological Activity: Pimasertib HCl is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.