PIM1 antibody

• Catalog Number: orb38744
• Category: Antibodies
• Description: Rabbit polyclonal antibody to PIM1 or pim-1 whose expression can be detected in the blood cells but it is majorly expressive in the erythrocytes. It is found in the nucleus. It can perform functions like apoptotic processes and shows oncogenic activity through: the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). It also acts as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Clone Number: RB15686
• Tested applications: IHC-P, WB
• Reactivity: Human
• Isotype: Rabbit IgG
• Immunogen: Recombinant Protein
• Dilution range: WB: 1:1000, IHC-P: 1:10-50
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Conjugation: Unconjugated
• MW: 35686
• Target: PIM1
• UniProt ID: P11309
• NCBI: NP_002639.1, NP_001230115.1
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Alternative names: anti-Oncogene PIM 1 antibody, anti-Oncogene PIM1 a
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

References

Xu, Jianwei et al. PIM-1 contributes to the malignancy of pancreatic cancer and displays diagnostic and prognostic value J Exp Clin Cancer Res, 35, 133 (2016)

PubMed: 27596051

Western blot analysis of 293 cell lysateusing PIM1 antibody (primary antibody dilution at: 1:1000)