PIAS1 (C) Antibody, Rabbit Polyclonal

• Catalog Number: orb67014
• Category: Antibodies
• Description: Rabbit polyclonal to PIAS1.E3 SUMO-protein ligase PIAS1 is a member of the mammalian PIAS (protein inhibitor of activatedSTAT-1 (signal transducer and activator of transcription-1)) family, which contains a putative zincbindingmotif and a highly acidic region. PIAS1 functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMOtetheringfactor. PIAS1 plays a crucial role as a transcriptional coregulation in various cellularpathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.In vitro, PIAS1 binds A/T-rich DNA. The effects of the transcriptional coregulation, transactivation orsilencing, may vary depending upon the biological context.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: IF, IHC, IP, WB
• Reactivity: Human, Mouse
• Immunogen: C-terminal region of human PIAS1
• Dilution range: WB:1:1000-1:5000,IP:1:50-1:100,IF:1:100-1:200,IHC:1:100-1:200
• Purity: antiserum
• Conjugation: Unconjugated
• MW: 72
• UniProt ID: O88907
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-PIAS1 antibody,anti-E3 SUMOprotein ligase PIA
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from mouse thymus using PIAS1 antibody

Western blot analysis of total cell extracts from ias1-plus or Pias1-minus mouse thymus using PIAS1 antibody