PHOX2B Antibody

• Catalog Number: orb1716140
• Category: Antibodies
• Description: Paired homeobox protein 2B (PHOX2B) is a transcription factor located on chromosome 4p13, which is essential for the formation of autonomic ganglia in the autonomic nervous system. PHOX2B is expressed in neuroblastoma, brain and adrenal glands. PHOX2B deficiency can lead to susceptibility to congenital central hypoventilation syndrome (CCHS) and neuroblastoma type 2 (NBLST2).
• Species/Host: Rabbit
• Clonality: Recombinant
• Clone Number: PHOX2B/7161R
• Tested applications: IHC-P
• Reactivity: Human
• Isotype: Rabbit IgG, kappa
• Immunogen: A human PHOX2B partial protein was used as the immunogen for the recombinant PHOX2B antibody.
• Dilution range: Immunohistochemistry (FFPE): 1-2ug/ml
• Conjugation: Unconjugated
• Formula: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Hazard Information: This recombinant PHOX2B antibody is available for research use only.
• UniProt ID: Q99453
• Storage: Aliquot the recombinant PHOX2B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Note: For research use only
• Application notes: Optimal dilution of the recombinant PHOX2B antibody should be determined by the researcher.
• Expiration Date: 12 months from date of receipt.

IHC staining of FFPE human renal cell carcinoma with recombinant PHOX2B antibody (clone PHOX2B/7161R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

IHC staining of FFPE human pancreas with recombinant PHOX2B antibody (clone PHOX2B/7161R). Negative control inset: PBS used instead of primary antibody to control for secondary Ab binding.