PF-8380

• Catalog Number: orb1303978
• Category: Small Molecules
• Description: PF-8380
• CAS Number: 1144035-53-9
• Purity: 99.45%
• MW: 478.33
• SMILES: C(CCN1CCN(C(OCC2=CC(Cl)=CC(Cl)=C2)=O)CC1)(=O)C=3C=C4C(=CC3)NC(=O)O4
• Formula: C₂₂H₂₁Cl₂N₃O₅
• Biological Activity: PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at the site of inflammation.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.