PF-5274857

• Catalog Number: orb1301768
• Category: Small Molecules
• Description: PF-5274857
• CAS Number: 1373615-35-0
• Purity: 98.99%
• MW: 436.96
• SMILES: ClC1=C(C=C(N=C1)N2CCN(C(CCS(C)(=O)=O)=O)CC2)C3=C(C)C=C(C)C=N3
• Formula: C₂₀H₂₅ClN₄O₃S
• Biological Activity: PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.PF-5274857 was found to effectively penetrate the blood-brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF-5274857 was orally available and metabolically stable in vivo.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.