PF-5274857 mseylate (1373615-35-0 free base)

• Catalog Number: orb1986875
• Category: Small Molecules
• Description: PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates.
• Purity: 98.00%
• MW: 533.06
• SMILES: O=C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)CCS(=O)(C)=O.OS(=O)(C)=O
• Formula: C₂₁H₂₉ClN₄O₆S₂
• Biological Activity: PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.