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Catalog Number | orb1706804 |
---|---|
Category | Small Molecules |
Description | PF-5006739 |
CAS Number | 1293395-67-1 |
Purity | 98.00% |
MW | 419.45 |
SMILES | Nc1nccc(n1)-c1c(ncn1C1CCN(Cc2ccon2)CC1)-c1ccc(F)cc1 |
Formula | C22H22FN7O |
Biological Activity | PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner. |
Storage | -20°C |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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