PF-5006739

• Catalog Number: orb1706804
• Category: Small Molecules
• Description: PF-5006739
• CAS Number: 1293395-67-1
• Purity: 98.00%
• MW: 419.45
• SMILES: Nc1nccc(n1)-c1c(ncn1C1CCN(Cc2ccon2)CC1)-c1ccc(F)cc1
• Formula: C₂₂H₂₂FN₇O
• Biological Activity: PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.