PF-3644022

• Catalog Number: orb1307895
• Category: Small Molecules
• Description: PF-3644022
• CAS Number: 1276121-88-0
• Purity: 99.12%
• MW: 374.46
• SMILES: O=C1C2=C(C=3C=4C(=NC(=CC4)C=5C=CC(C)=NC5)C=CC3S2)NC[C@@H](C)N1
• Formula: C₂₁H₁₈N₄OS
• Biological Activity: PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) (IC50s: 53 nM and 5.0 nM, respectively).
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.