PAR-4 Agonist Peptide, amide TFA

SKU: orb1296768

Description

PAR-4 Agonist Peptide, amide TFA

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1228078-65-6
• MW: 794.82
• Purity: 99.72%
• Formula: C₃₆H₄₉F₃N₈O₉
• SMILES: OC(=O)C(F)(F)F.C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
• Target: Protease-activated Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (6.29 mM);DMSO:250 mg/mL (314.54 mM);H2O:100 mg/mL (125.81 mM)

Bioactivity

• In Vivo:
  SCID mice demonstrate a markedly enhanced abdominal response to colorectal distension (CRD), with distension levels ranging from 0.04 to 0.1 mL amplifyin the intensity o the EMG response from 384% to 132%, respectively as compared to BALB/cBy controls ( < .01; < .01; < .01; < .001). Activation of PAR-4 significantly mitigates this hypersensitivity ( < .01, < .05; < .05; < .05.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

AY-NH2, AY-NH2 (TFA), inhibit, PAR 4 Agonist Peptide, amide TFA, PAR-4-AP (TFA), PAR4 Agonist Peptide, amide TFA, PAR-4 Agonist Peptide, amide TFA, PAR-4-AP, PAR-4 Agonist Peptide, amide, PAR-4, Inhibitor, Thrombin receptors, Protease Activated Receptor (PAR), ProteaseactivatedReceptor, Proteaseactivated Receptor, Protease-Activated Receptor (PAR)

Compound Identifiers

PubChem CID

71311736